Description
Indication & Scope
TARGINACT® (Oxycodone Hydrochloride and Naloxone Hydrochloride Prolonged Release Tablets) is a prescription opioid combination analgesic indicated for the management of severe persistent pain in adults requiring opioid analgesics for adequate pain control. The combination of oxycodone and naloxone provides strong analgesia while reducing opioid-induced constipation (OIC) through peripheral intestinal opioid receptor antagonism.
- Mechanism: Oxycodone activates central μ-opioid receptors to provide potent analgesic effects. Naloxone selectively blocks peripheral intestinal μ-opioid receptors to reduce opioid-related constipation without significantly affecting central analgesia.
- Drug class: Opioid analgesic combination (controlled narcotic medication).
- Clinical use: Long-term management of severe cancer pain and other severe chronic pain conditions requiring opioid therapy.
| Generic Name | Oxycodone Hydrochloride and Naloxone Hydrochloride Prolonged Release Tablets |
| Brand Name | TARGINACT® |
| Ingredient | Oxycodone Hydrochloride + Naloxone Hydrochloride |
| Dosage Form | Prolonged Release Tablet |
| Package | 5 mg oxycodone HCl + 2.5 mg naloxone HCl per tablet, 14 tablets/carton |
| Conditions Treated | Severe persistent pain requiring opioid analgesics, including cancer pain and severe chronic pain |
| Taboos | Hypersensitivity to oxycodone, naloxone, or excipients; severe respiratory depression; severe hepatic impairment; pregnancy, lactation, pediatric patients |
| Place of origin | UNITED KINGDOM |
| Prescription type | Prescription Drug (Rx) |
| Storage Conditions | Store below 25°C in a dry place, protected from light. Store under controlled medication management requirements. |
| Manufacturer | BARD PHARMACEUTICALS LIMITED |
| Registration Authority | National Medical Products Administration (NMPA), China |
| Approval Number | HJ20220086 |
| Approval Date | April 12, 2023 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: The recommended starting dose is 5 mg/2.5 mg every 12 hours, followed by gradual dose adjustment according to pain severity and individual tolerance.
Time: Administer every 12 hours at fixed times, usually morning and evening.
Instructions for use: Swallow the tablet whole with water. Do not crush, chew, split, or grind the tablet, as damaging the prolonged-release structure may cause rapid release of oxycodone and increase the risk of severe respiratory depression. Treatment should be individually titrated and discontinued gradually after long-term use to avoid withdrawal symptoms.
Interaction: Avoid concurrent use with alcohol, benzodiazepines, sedatives, hypnotics, other opioids, or monoamine oxidase inhibitors (MAOIs) due to increased risk of respiratory and central nervous system depression.
Side effects: Common adverse reactions include drowsiness, dizziness, nausea, vomiting, dry mouth, fatigue, constipation, sweating, and hypotension. Serious reactions may include respiratory depression, dependence, and withdrawal syndrome.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indication, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is TARGINACT® (Oxycodone Hydrochloride and Naloxone Hydrochloride Prolonged Release Tablets) used for?
TARGINACT® (Oxycodone Hydrochloride and Naloxone Hydrochloride Prolonged Release Tablets) is used for the treatment of severe persistent pain in adults who require opioid analgesic therapy.
What is the role of naloxone in this product?
Naloxone mainly acts locally in the intestine to reduce opioid-induced constipation while maintaining oxycodone-mediated pain relief.
Can the tablet be crushed or divided?
No. The prolonged-release tablet must be swallowed whole. Crushing or chewing may cause rapid drug release and increase overdose risk.
Can TARGINACT® (Oxycodone Hydrochloride and Naloxone Hydrochloride Prolonged Release Tablets) be used with alcohol or sleeping medicines?
No. Combination with alcohol, benzodiazepines, or other central nervous system depressants may increase the risk of life-threatening respiratory depression.
TARGINACT® | Oxycodone Hydrochloride and Naloxone Hydrochloride | Severe Pain | DengYueRX
INN: Oxycodone Hydrochloride and Naloxone Hydrochloride
Indications: Severe Persistent Pain Relief
Dosage Form: Prolonged Releas Tablet
Strength: 5 mg oxycodone HCl + 2.5 mg naloxone HCl/Tablet
Original price was: $33.28.$28.29Current price is: $28.29.
