Description
Indication & Scope
Mannitol Injection is a prescription osmotic diuretic indicated for the reduction of intracranial pressure and cerebral edema, reduction of intraocular pressure, promotion of diuresis in selected patients with acute kidney injury risk, and enhancement of urinary excretion of certain toxic substances.
- Mechanism: Mannitol increases plasma osmolality, drawing water from intracellular and interstitial spaces into the intravascular compartment. It is filtered by the glomeruli but minimally reabsorbed, producing osmotic diuresis.
- Drug class: Osmotic diuretic.
- Clinical use: Treatment of cerebral edema and elevated intracranial pressure, reduction of intraocular pressure before ophthalmic surgery, promotion of diuresis in selected patients, and adjunctive management of certain poisonings.
| Generic Name | Mannitol Injection |
| Brand Name | KeLun Pharma® |
| Ingredient | Mannitol |
| Dosage Form | Injection |
| Package | 20% (50 g/250 ml)/plastic bottle |
| Conditions Treated | Cerebral edema, elevated intracranial pressure, elevated intraocular pressure, oliguria requiring diagnostic evaluation or diuresis, selected drug intoxications |
| Taboos | Established anuria due to severe renal disease, severe dehydration, active intracranial bleeding (except during craniotomy), pulmonary edema, severe pulmonary congestion, hypersensitivity to mannitol |
| Place of origin | China |
| Prescription type | Prescription Drug (Rx) |
| Storage Conditions | Store at room temperature. Protect from freezing. Warm and dissolve crystals completely before use if crystallization occurs. |
| Manufacturer | Hunan Kelun Pharmaceutical Co., Ltd. |
| Registration Authority | National Medical Products Administration (NMPA), China |
| Approval Number | H43020481 |
| Approval Date | April 14, 2025 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose: For cerebral edema or elevated intracranial pressure, 0.25–1 g/kg by intravenous infusion; dosage should be individualized according to the patient’s condition and response.
Time: Administer by intravenous infusion over 30–60 minutes. Use an infusion filter for concentrated solutions if crystals are present or have been dissolved.
Instructions for use: For intravenous use only. Inspect the solution before administration. If crystals are present, warm until completely dissolved and allow the solution to cool before use. Monitor serum electrolytes, renal function, urine output, and serum osmolality during treatment.
Interaction: Use caution with nephrotoxic drugs, digoxin, lithium, and blood products. Do not infuse through the same line as whole blood.
Side effects: Common adverse reactions include fluid and electrolyte imbalance, dehydration, headache, nausea, thirst, polyuria, pulmonary edema in susceptible patients, phlebitis, and renal impairment with excessive or prolonged use.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indication, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is Mannitol Injection used for?
It is primarily used to rapidly reduce intracranial pressure and cerebral edema, lower intraocular pressure, and promote osmotic diuresis in selected clinical situations.
Why do mannitol solutions sometimes contain crystals?
Mannitol may crystallize at low temperatures. The solution should be warmed until the crystals dissolve completely before administration.
Can Mannitol Injection be used in patients with kidney failure?
It is contraindicated in patients with established anuria due to severe renal disease because accumulation may increase the risk of fluid overload and osmotic nephrosis.
What should be monitored during treatment?
Serum osmolality, electrolytes, renal function, urine output, and fluid balance should be monitored closely.
KeLun Pharma® | Mannitol | Cerebral Edema | DengYueRX
INN: Mannitol
Indications: Cerebral edema
Dosage Form: Injection
Strength: 20% (50 g/250 mL)
Original price was: $1.21.$1.03Current price is: $1.03.
