Description
Indication & Scope
Isavuconazonium sulfate converts into active isavuconazole in vivo, which inhibits fungal CYP51 enzyme to block ergosterol synthesis and destroy fungal cell membrane. It retains activity against mucorales strains insensitive to voriconazole.
- Mechanism
Triazole broad-spectrum antifungal prodrug - Drug class
Oral systemic anti-infective / Deep mycosis therapeutic capsule - Clinical use
Novel oral triazole antifungal prodrug, stable oral absorption, wide antifungal spectrum against aspergillus, mucorales and partially azole-resistant fungi, suitable for long-term maintenance treatment of immunocompromised patients with deep mycosis.
| Generic Name | Isavuconazonium Sulfate Capsules |
| Brand Name | Cresemba® |
| Ingredient | Isavuconazonium Sulfate |
| Dosage Form | Oral Hard Capsules |
| Package | 100mg*7 capsules*2 blisters (calculated as C₂₂H₁₇F₂N₅OS) / box |
| Conditions Treated | Treatment of adult invasive aspergillosis; invasive mucormycosis for patients unsuitable for amphotericin B therapy; also for children aged ≥6 years with body weight ≥32kg suffering from above severe invasive fungal infections. |
| Taboos | Patients with hypersensitivity to isavuconazonium sulfate, triazole antifungals or any capsule excipients are forbidden. Concomitant use with strong CYP3A4 inducers is prohibited. |
| Place of origin | Switzerland |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | SwissCo Services AG |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20210079 |
| Approval Date | December 14, 2021 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: Oral administration, swallow capsules whole with water, with or without meals.
Time: Loading dose: 2 capsules every 8 hours for total 6 doses (48 hours); Maintenance dose: 2 capsules once daily afterwards.
Instructions for use: Do not co-administer with strong CYP3A4 inducers. Monitor liver function regularly during treatment.
Interaction: Strong CYP3A4 inducers and acid-suppressing medicines sharply lower absorption and cause treatment failure.
Side effects: Mild nausea, vomiting, diarrhea, headache, elevated liver transaminase.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indicatiaon, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
Is isavuconazole safe for the liver?
Isavuconazole can induce hepatotoxicity including elevated liver chemistry tests or hepatitis.
What unique advantage does this triazole antifungal possess?
It covers mucormycosis that voriconazole cannot treat, with milder renal adverse reactions.
What is the active metabolite of isavuconazonium sulfate in vivo?
It is rapidly converted into isavuconazole after oral absorption.
Is it allowed to split or chew the capsules before taking?
No, the capsules must be swallowed whole with water without breaking or chewing.
Cresemba® | Isavuconazonium Sulfate Capsules | IA And IM | DengYueRX
INN: Isavuconazonium Sulfate
Indications: IA (Invasive Aspergillosis) And IM (Invasive Mucormycosis)
Dosage Form: Oral Hard Capsules
Strength: 100mg (calculated as C₂₂H₁₇F₂N₅OS) / Capsule
Original price was: $592.56.$503.68Current price is: $503.68.
Low MOQ
WHO-GMP
Worldwide Delivery
Compliance and Regulatory Documents
Related Products
