Description
Indication & Scope
Niraparib Tosylate and Abiraterone Acetate Tablets (Akeega®) combines abiraterone acetate (androgen synthesis inhibitor) and niraparib (PARP inhibitor) to trigger synthetic lethality and curb BRCA-mutated mCRPC cell growth.
- Mechanism
Fixed combination of androgen synthesis inhibitor + PARP inhibitor - Drug class
Prescription oral combined targeted therapy for prostate cancer - Clinical use
BRCA-mutated metastatic castration-resistant prostate cancer combined with prednisone
| Generic Name | Niraparib Tosylate and Abiraterone Acetate Tablets |
| Brand Name | Akeega® |
| Ingredient | Niraparib Tosylate and Abiraterone Acetate |
| Dosage Form | Film-coated Tablets |
| Package | 50mg/500mg*56 tablets/box |
| Conditions Treated | Combined with prednisone/prednisolone for adult patients with metastatic castration-resistant prostate cancer (mCRPC) harboring BRCA1/BRCA2 gene mutations |
| Taboos | Pregnant, breastfeeding women; Women of childbearing potential without protective gloves for drug handling; Patients hypersensitive to niraparib, abiraterone acetate or any excipients |
| Place of origin | Bourgoin-Jallieu, France |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | Patheon France |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20240110 |
| Approval Date | October 16, 2024 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: Standard dosage regimen: 1 tablet orally once daily, taken on an empty stomach at least 2 hours before food and 1 hour after food.
Time: Daily fixed-time oral administration on empty stomach; continuous treatment until disease progression or intolerable toxicity.
Interaction: Strong CYP3A4 inhibitors increase systemic exposure of abiraterone, close monitoring is required for combined use; strong CYP3A4 inducers reduce efficacy, concurrent use forbidden. Niraparib may aggravate myelosuppression when combined with chemotherapy.
Side effects: Common reactions: Anemia, thrombocytopenia, neutropenia, hypertension, hypokalemia, elevated liver transaminases, fatigue, hot flushes, joint pain, nausea.
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What drugs are forbidden to combine with abiraterone acetate?
Strong CYP3A4 inducers and exogenous androgens.
What severe hematologic adverse reaction is mainly induced by niraparib tosylate?
Bone marrow suppression including anemia, neutropenia and thrombocytopenia.
Why can pregnant women not touch this medicine without gloves?
Both niraparib tosylate and abiraterone acetate may cause fetal developmental damage.
What auxiliary glucocorticoid must be used together with the combination tablet?
Prednisone or prednisolone.
Akeega® | Niraparib Tosylate and Abiraterone Acetate Tablets | DengYueRX
INN: Niraparib Tosylate and Abiraterone Acetate
Indications: MCRPC (metastatic castration-resistant prostate cancer)
Dosage Form: Film-coated Tablets
Strength: 50mg/500mg/Tablet
Original price was: $2,016.55.$1,714.07Current price is: $1,714.07.
