Description
Indication & Scope
Tacrolimus Capsules inhibits calcineurin, blocks T lymphocyte activation and reduces inflammatory cytokine release. It suppresses immune response to prevent transplant organ rejection.
- Mechanism
Calcineurin inhibitor / Potent immunosuppressant - Drug class
Oral systemic immunosuppressant / Transplant anti-rejection capsules - Clinical use
Potent calcineurin inhibitor immunosuppressant; suppresses lymphocyte activation, core medication for solid organ transplant anti-rejection therapy.
| Generic Name | Tacrolimus Capsules |
| Brand Name | SaiFuKai®; Advagraf® |
| Ingredient | Tacrolimus |
| Dosage Form | Oral Hard Capsules; Sustained-release Capsules |
| Package | 0.5mg*50 capsules/box |
| Conditions Treated | Prophylaxis of graft rejection after liver or kidney transplantation; treat refractory graft rejection uncontrolled by other immunosuppressants post liver and kidney transplantation. |
| Taboos | Patients hypersensitive to tacrolimus or other macrolides are forbidden. |
| Place of origin | China; Ireland |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.; Astellas Ireland Co. Limited |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | H20094027; HJ20150029 |
| Approval Date | May 31, 2023; July 10, 2024 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose:Oral administration, swallow whole with water.
Time: Administered twice daily, morning and evening, preferably on an empty stomach.
Instructions for use: Regular monitoring of tacrolimus blood trough level, renal function and blood pressure is essential. Grapefruit juice must be avoided. Reliable contraception is required during treatment.
Interaction: Drugs affecting CYP3A4 will alter tacrolimus blood concentration; regular trough concentration monitoring is required. Combined nephrotoxic agents increase renal damage risk.
Side effects: Tremor, hypertension, renal function impairment, hyperglycemia, insomnia.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indicatiaon, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is the main indication of Saifukai?
Prevent and treat graft rejection after kidney and liver transplantation.
Should Tacrolimus Capsules be taken with food?
Better take on an empty stomach to stabilize blood concentration.
Does dosage of Tacrolimus Capsules need adjustment combined with CYP3A4 inhibitors?
Yes, blood drug concentration will rise, dosage should be reduced.
What common adverse reaction may appear during Tacrolimus Capsules treatment?
Hand tremor, high blood pressure and abnormal renal function.
SaiFuKai® | Tacrolimus Capsules | Graft Rejection | DengYueRX
INN: Tacrolimus
Indications: Graft Rejection
Dosage Form: Oral Hard Capsules; Sustained-release Capsules
Strength: 0.5mg/Capsule
Price range: $81.43 through $90.20
