depakine compound sodium valproate and valproic acid sustained release tablets I 0

Description

Indication & Scope

Sodium valproate elevates brain GABA concentration and blocks abnormal neuronal electrical discharge to suppress epileptic seizures. It stabilizes mood by regulating central glutamatergic and GABAergic pathways for bipolar mania control.

Mechanism
GABA enhancer / Broad-spectrum anti-epileptic & mood stabilizer
Drug class
Prescription oral sustained-release anti-epileptic tablets
Clinical use
Epilepsy, manic episodes of bipolar disorder

Specification

Generic Name	Sodium Valproate Sustained-Release Tablets (I)
Brand Name	Depakine®
Ingredient	Sodium Valproate
Dosage Form	Sustained-Release Tablets
Package	0.5g*30 tablets/box
Conditions Treated	Epilepsy (monotherapy or adjunctive therapy): Generalized epilepsy including absence, myoclonic, tonic-clonic, atonic and mixed seizures; partial epilepsy with or without secondary generalization; special epilepsy syndromes (West, Lennox-Gastaut)
Taboos	Hypersensitivity to valproate or any excipients
Place of origin	China
Priscription Type	Prescription Drug
Storage Conditions	Sealed, store below 30°C, protected from light
Manufacturer	Sanofi (Hangzhou) Pharmaceutical Co., Ltd.
Registration Authority	National Medical Products Administration (NMPA)
Approval number	H20010595
Approval Date	June 28, 2024
Shelf Life	36 months

How to use ?

Recommended Dose: 10–15mg/kg daily, titrate up to 20–30mg/kg; maximum daily dose 3000mg.

Time: Long-term maintenance to prevent seizure recurrence; gradual dose tapering is mandatory before discontinuation to avoid life-threatening status epilepticus.

Interaction: Valproate inhibits CYP2C9, CYP2C19 and CYP3A4; combined carbamazepine, lamotrigine, warfarin need dose adjustment and blood concentration monitoring. Avoid combined hepatotoxic drugs.

Side effects: Gastrointestinal discomfort, tremor, weight gain, transient liver enzyme elevation, hair loss.

Important Notice

This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.

Packaging & Shipping

Packaging

Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.

Shipping Methods

Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.

Export Support

Certificate of Analysis

GMP Certificate

Commercial Invoice

Packing List & CPP

Cold Chain Logistics

Customs Documentation

Scientific and regulatory sources

1.WHO References

2.NMPA

3.FDA

4.EMA

FAQ

What is sodium valproate used for?

To treat epilepsy and bipolar disorder.

Is sodium valproate a high risk drug?

There are high risks if valproate is taken while pregnant.

What are the benefits of valproate?

It helps to treat the symptoms of mania by reducing feelings of excitability and over-activity.

Does sodium valproate help ADHD?

Valproate-induced ADHD involves complex neurochemistry. Brain serotonin tightly links to hyperactivity/impulsivity (Castellanos, 1995), explaining valproate-triggered overactive behaviors.