Description
Indication & Scope
Humalog Mix50® is a biphasic insulin analog containing 50% rapid-acting insulin lispro and 50% intermediate-acting insulin lispro protamine suspension, indicated for improving glycemic control in adults with type 1 or type 2 diabetes mellitus requiring insulin therapy. The rapid-acting component controls postprandial blood glucose excursions, while the protamine suspension provides prolonged basal insulin coverage throughout the day. It is particularly suitable for patients with prominent post-meal hyperglycemia.
- Mechanism: Insulin lispro rapidly promotes peripheral glucose uptake and suppresses hepatic glucose production after meals, while insulin lispro protamine suspension slowly releases insulin to provide intermediate-duration basal glycemic control.
- Drug class: Biphasic insulin analog (premixed insulin analogue).
- Clinical use: Glycemic control in adults with type 1 or type 2 diabetes mellitus requiring insulin therapy. May be used alone or together with oral antidiabetic agents such as metformin when clinically appropriate.
| Generic Name | Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R) |
| Brand Name | Humalog Mix50® |
| Ingredient | 50% Insulin Lispro + 50% Insulin Lispro Protamine Suspension |
| Dosage Form | Pen cartridge injection |
| Package | 300 IU/3 mL/cartridge, 1 cartridge/box |
| Conditions Treated | Type 1 diabetes mellitus; Type 2 diabetes mellitus requiring insulin therapy |
| Taboos | Hypersensitivity to insulin lispro or any excipient; episodes of hypoglycemia |
| Place of origin | France |
| Prescription type | Prescription Drug (Rx) |
| Storage Conditions | Store refrigerated at 2–8°C before first use. Do not freeze. After first use, store below 30°C and use within 28 days. |
| Manufacturer | Lilly France |
| Registration Authority | National Medical Products Administration (NMPA), China |
| Approval Number | SJ20171023 |
| Approval Date | July 20, 2022 |
| Shelf Life | 30 months |
How to use ?
Recommended Dose: Individualized according to blood glucose monitoring and clinical response. Humalog Mix50® is typically administered once or twice daily.
Time: Inject within 15 minutes before a meal.
Instructions for use: For subcutaneous injection only. Inject into the abdomen, thigh, upper arm, or buttock, rotating injection sites regularly to reduce the risk of lipodystrophy. Gently roll and invert the cartridge until the suspension appears uniformly milky before each injection. Do not administer intravenously or via an insulin infusion pump.
Interaction: The glucose-lowering effect may be enhanced by other antidiabetic medications, including metformin, sulfonylureas, GLP-1 receptor agonists, and SGLT2 inhibitors, while corticosteroids, thyroid hormones, sympathomimetics, and certain diuretics may reduce its efficacy. Dose adjustment and regular blood glucose monitoring may be required.
Side effects: The most common adverse reactions include hypoglycemia, injection-site reactions, lipodystrophy, weight gain, edema, and, rarely, allergic reactions.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indication, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is Humalog Mix50® (Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R)) used for?
Humalog Mix50® (Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R)) is used to improve blood glucose control in adults with type 1 or type 2 diabetes mellitus who require insulin therapy.
When should Humalog Mix50® (Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R)) be injected?
Inject within 15 minutes before meals.
Can Humalog Mix50® (Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R)) be given intravenously?
No. Humalog Mix50® (Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection(50R)) is intended only for subcutaneous injection.
Should the suspension be mixed before injection?
Yes. Roll and invert the cartridge gently until the liquid becomes evenly cloudy before each injection.
Humalog Mix50® | Mixed Protamine Zinc Recombinant Human Insulin Lispro | Diabetes Mellitus | DengYueRX
INN: Mixed protamine zinc recombinant human insulin lispro
Indications: Type 1 and Type 2 diabetes mellitus
Dosage Form: Pen cartridge injection
Strength: 300 IU/3 mL/Cartridge
Original price was: $10.44.$8.88Current price is: $8.88.
