Description
Indication & Scope
Amisulpride Tablets (PaKe®) (Solian®) are a selective dopamine D2/D3 receptor antagonist. Low doses selectively block presynaptic dopamine autoreceptors to increase dopamine release and improve negative symptoms and depression; high doses block postsynaptic D2/D3 receptors to control psychotic positive symptoms.
- Mechanism
Selective D2/D3 dopamine receptor antagonist (atypical antipsychotic) - Drug class
Prescription oral atypical antipsychotic tablets - Clinical use
Schizophrenia, mild-moderate depressive episodes
| Generic Name | Amisulpride Tablets |
| Brand Name | PaKe®; Solian® |
| Ingredient | Amisulpride |
| Dosage Form | Film-coated Tablets; Uncoated Plain Tablets |
| Package | 50mg*20 tablets/box; 0.2g*20 tablets/box |
| Conditions Treated | Acute and chronic schizophrenia, including patients with predominant positive symptoms (hallucination, delusion, agitation) and/or negative symptoms (apathy, social withdrawal, lack of speech) |
| Taboos | Hypersensitivity to amisulpride or any excipients |
| Place of origin | China; France |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | Qilu Pharmaceutical Co., Ltd.; Delpharm Dijon |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | H20113230; HJ20171121 |
| Approval Date | February 21, 2025; September 01, 2023 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: Schizophrenia with dominant negative symptoms: 50–100mg once daily, maximum 300mg/day
Time: Long-term maintenance treatment is required for schizophrenia to prevent relapse; depressive episodes are treated continuously until emotional symptoms fully relieve.
Interaction: Contraindicated with levodopa. Caution when combined with drugs that prolong QT interval, risk of arrhythmia.
Side effects: Insomnia, anxiety, agitation, prolactin elevation (galactorrhea, amenorrhea, breast swelling, sexual dysfunction), weight gain, mild extrapyramidal symptoms.
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
Why does low-dose amisulpride improve apathy and social withdrawal of schizophrenia?
Low doses selectively block presynaptic dopamine autoreceptors, boost dopamine release in frontal lobe to relieve negative symptoms.
Can patients driving or operating machines take Pake?
Not recommended; the drug causes drowsiness, which impairs attention and reaction speed.
Which two types of drugs are absolutely forbidden to combine with amisulpride?
Levodopa, and all medicines that prolong QT interval to trigger torsades de pointes.
Will hyperprolactinemia adverse reactions recover after drug discontinuation?
Yes, galactorrhea, irregular menstruation and sexual dysfunction will gradually disappear after stopping medication.
PaKe® | Amisulpride Tablets | Schizophrenia | DengYueRX
INN: Amisulpride
Indications: Schizophrenia
Dosage Form: Film-coated Tablets; Uncoated Plain Tablets
Strength: 50mg/Tablet; 0.2g/Tablet
Price range: $2.14 through $6.64
