Description
Indication & Scope
Amphotericin B binds to ergosterol on fungal cell membrane to form transmembrane pores, leading to leakage of intracellular contents and fungal death. It has strong broad-spectrum activity against almost all pathogenic fungi.
- Mechanism
Polyene antifungal agent - Drug class
Systemic anti-fungal injection - Clinical use
This polyene antifungal damages fungal cell membrane to kill fungi, applicable for life-threatening visceral and invasive fungal infections unresponsive to other antifungals.
| Generic Name | Amphotericin B for Injection |
| Brand Name | XinOuBo®; Ambisome® |
| Ingredient | Amphotericin B |
| Dosage Form | Injection; Liposomal Injection |
| Package | 5mg/vial/box; 50mg/vial/box |
| Conditions Treated | For severe systemic deep fungal infections caused by candida, cryptococcus, aspergillus and other sensitive fungi. |
| Taboos | Patients allergic to amphotericin B or any excipients of this preparation are prohibited from using this medicine. |
| Place of origin | China; America |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | North China Pharmaceutical Co., Ltd.; Gilead Sciences Inc. |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | H13020285; HJ20233123 |
| Approval Date | December 27, 2024; February 28, 2023 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose: Intravenous drip only, reconstitute with sterile water then dilute in glucose injection.
Time: Slow intravenous infusion over 6 hours, avoid rapid injection.
Interaction: Combined nephrotoxic drugs (aminoglycosides, ciclosporin) will aggravate kidney damage; avoid concurrent use if possible.
Side effects: Chills, fever, renal function damage, hypokalemia, nausea and vomiting.
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What are the benefits of amphotericin B?
It is an antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Does amphotericin B make you tired?
Notify your health care provider right away if you feel unusually weak or tired.
Why is amphotericin B not given orally?
Due to its physical and chemical properties, its limited water and lipid solubility, and its very poor oral absorption.
Is it a strong antifungal?
It is generally considered cidal against susceptible fungi at clinically relevant concentrations.
XinOuBo® | Amphotericin B for Injection | Fungal Sepsis | DengYueRX
INN: Amphotericin B
Indications: Fungal Sepsis
Dosage Form: Injection; Liposomal Injection
Strength: 5mg/Vial; 50mg/Vial
Price range: $16.07 through $126.43
