Description
Indication & Scope
Doxorubicin Hydrochloride Liposome Injection (Caelyx®) is a long-cycle PEGylated liposomal anthracycline cytotoxic chemotherapy drug. It intercalates into DNA, inhibits nucleic acid synthesis, suppresses tumor cell replication; the liposome formulation prolongs circulation time, improves tumor targeting and reduces systemic toxicity, especially cardiac toxicity.
- Mechanism
Intercalate DNA, inhibit DNA/RNA synthesis and tumor cell proliferation; long-circulating liposome delivery - Drug class
Anthracycline cytotoxic chemotherapy / Liposomal targeted chemotherapeutic agent - Clinical use
AIDS-related Kaposi’s sarcoma (AIDS-KS)
| Generic Name | Doxorubicin Hydrochloride Liposome Injection |
| Brand Name | Caelyx® |
| Ingredient | Doxorubicin Hydrochloride Liposome |
| Dosage Form | Liposome Injection |
| Package | 10ml:20mg/vial |
| Conditions Treated | AIDS-related Kaposi’s sarcoma (AIDS-KS) in patients with low CD4 count (<200 CD4 lymphocytes/mm³) and extensive mucocutaneous/visceral disease |
| Taboos | Hypersensitivity to doxorubicin, anthracyclines or any excipients; pregnancy |
| Place of origin | India |
| Priscription Type | Prescription Drug |
| Storage Conditions | Store at 2–8℃, do NOT freeze |
| Manufacturer | Natco Pharma Limited |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | H20050189 |
| Date of Revision | July 18, 2013 |
| Shelf Life | 18 months |
How to use ?
Recommended Dose: 20mg/m² intravenous infusion every 2–3 weeks, diluted with 5% glucose injection, infused over 30 minutes or longer; do not give intramuscularly or subcutaneously
Time: Infuse slowly, avoid rapid injection; dosing interval no less than 10 days
Interaction: Monitor with cardiotoxic drugs, avoid incompatible diluents; strict aseptic manipulation
Side effects: Bone marrow suppression (neutropenia), mucositis, hand-foot syndrome, infusion reactions, cardiotoxicity, alopecia, nausea
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is the correct diluent for infusion?
5% glucose injection only.
What route of administration is forbidden?
Intramuscular injection and subcutaneous injection.
Can it be directly substituted with conventional doxorubicin?
No, different pharmacokinetics, cannot be arbitrarily interchanged.
What is the core drug class of this medicine?
PEGylated liposomal anthracycline cytotoxic chemotherapy drug.
Caelyx® | Doxorubicin Hydrochloride Liposome Injection | AIDS-KS | DengYueRX
INN: Doxorubicin Hydrochloride
Indications: AIDS-KS (AIDS-related Kaposi’s sarcoma)
Dosage Form: Liposome Injection
Strength: 10ml:20mg/Vial
Original price was: $498.15.$423.43Current price is: $423.43.
