Description
Indication & Scope
Irinotecan Hydrochloride Injection(Campto®) is a topoisomerase I inhibitor cytotoxic chemotherapeutic agent. Its active metabolite SN-38 inhibits topoisomerase I, stabilizes DNA single-strand breaks, blocks DNA replication and transcription, leading to tumor cell death. It is core medication for gastrointestinal malignant tumors.
- Mechanism
Inhibit topoisomerase I, damage tumor cell DNA, block cell division - Drug class
Topoisomerase I inhibitor cytotoxic chemotherapy drug - Clinical use
MCRC first/second-line treatment, combined chemotherapy for AGC
| Generic Name | Irinotecan Hydrochloride Injection |
| Brand Name | Campto® |
| Ingredient | Irinotecan Hydrochloride |
| Dosage Form | Injection |
| Package | 2ml:40mg/vial |
| Conditions Treated | Metastatic colorectal cancer (mCRC) first-line combined chemotherapy with fluoropyrimidines; mCRC second-line treatment after fluoropyrimidine regimen failure; Combined therapy for advanced gastric cancer (AGC) |
| Taboos | Hypersensitivity to irinotecan; severe hepatic dysfunction; chronic inflammatory bowel disease; obstructive intestinal disease; pregnant & lactating women |
| Place of origin | Gujarat, India |
| Priscription Type | Prescription drug (Rx) |
| Storage Conditions | Store below 25℃, protected from light, do not freeze |
| Manufacturer | Zydus Hospira Oncology Pvt Ltd |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20160578 |
| Approval Date | July 01, 2025 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose: 180mg/m² intravenous infusion over 90 minutes once every 2 weeks, combined with fluoropyrimidines; premedicate anti-cholinergic drugs to prevent early diarrhea
Time: Biweekly cycle; monitor delayed diarrhea closely within 24–48h after infusion
Interaction: Avoid strong CYP3A4 inducers/inhibitors; St. John’s Wort is forbidden
Side effects: Delayed diarrhea, neutropenia, cholinergic syndrome (sweating, abdominal cramp), nausea and vomiting, fatigue
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
Which organ mainly metabolizes irinotecan in human body?
Liver.
What symptom belongs to acute cholinergic syndrome after medication?
Abdominal cramping, excessive sweating.
What examination should be completed before each treatment cycle?
Routine blood test.
Why should patients avoid laxatives during medication?
It will aggravate drug-induced diarrhea.
Campto® | Irinotecan Hydrochloride Injection | MCRC and AGC | DengYueRX
INN: Irinotecan Hydrochloride
Indications: MCRC (metastatic colorectal cancer) and AGC (advanced gastric cancer)
Dosage Form: Injection
Strength: 2ml:40mg/Vial
Original price was: $155.16.$131.88Current price is: $131.88.
