Recommended Dose: The recommended starting dose is 1 mg once daily for 4 weeks, followed by 2 mg once daily if needed to achieve the target serum uric acid level. The maximum recommended dose is 4 mg once daily.

Time: Take orally once daily at the same time each day, with or without food.

Instructions for use: Swallow the tablet with water and maintain adequate hydration throughout treatment. Because gout attacks may occur during the initial stage of urate-lowering therapy, treatment should generally be continued, and prophylactic anti-inflammatory therapy may be considered.

Interaction: Use caution when combined with other uricosuric agents or diuretics due to an increased risk of kidney stones. Dotinurad may be used together with xanthine oxidase inhibitors such as febuxostat or allopurinol when clinically appropriate.

Side effects: Common adverse reactions include gout flare, increased liver enzymes, diarrhea, abdominal discomfort, headache, dizziness, and kidney stones. Rare but serious reactions include severe hypersensitivity, liver injury, and acute kidney injury.