Description
Indication & Scope
Tegileridine Fumarate Injection relieves moderate to severe acute postoperative pain following abdominal surgery.
- Mechanism: Biased μ-opioid receptor agonist; selectively activates G-protein analgesic pathways with low β-arrestin recruitment, reducing respiratory and gastrointestinal opioid side effects.
- Drug class: Biased mu-opioid analgesic, injectable controlled prescription opioid.
- Clinical use: Short-term postoperative pain control after abdominal surgery for moderate-severe nociceptive pain.
| Generic Name | Tegileridine Fumarate Injection |
| Brand Name | AiSuTe |
| Ingredient | Tegileridine Fumarate Injection |
| Dosage Form | Injection |
| Package | 1ml: 1mg*10 vials/box; 5ml: 5mg*10 vials/box |
| Conditions Treated | Moderate to severe acute pain post abdominal surgery |
| Taboos | 1. Hypersensitivity to tegileridine, fumarate or injection excipients
2. Severe respiratory depression, untreated respiratory insufficiency 3. Acute intestinal obstruction, paralytic ileus 4. Concurrent use with monoamine oxidase inhibitors (MAOIs) within 14 days |
| Place of origin | China |
| Prescription type | Prescription-only |
| Storage Conditions | Store at 15°C–30°C, protect from freezing and light |
| Manufacturer | HengRui Pharmaceutical Co., Ltd |
| Registration Authority | National Medical Products Administration (NMPA), China |
| Approval number | H20240006 |
| Date of Revision | 2024 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose: 0.75–1.0 mg IV bolus once; repeated doses administered by anesthesiologist based on pain score.
Time: Administered intravenously in post-operative recovery ward upon pain onset.
Instructions for use:
1. Only administered by trained anesthesiology staff.
2. Continuously monitor respiration, blood pressure and oxygen saturation.
3. Avoid rapid high-dose bolus to prevent respiratory suppression.
4. Do not mix with alkaline injection solutions.
Interaction:
1. Sedatives, benzodiazepines, general anesthetics amplify respiratory depression
2. Alcohol potentiates central nervous system suppression.
3. Serotonergic antidepressants carry serotonin syndrome risk.
Side effects:
1. Common: Nausea, vomiting, dizziness, somnolence, hypotension, injection site pain.
2. Severe: Respiratory arrest, bradycardia, severe hypotension, anaphylactic shock.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indicatiaon, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is Tegileridine Fumarate's onset and duration of analgesic effect following intravenous administration?
Onset is rapid (within minutes), with peak effect at 5–10 minutes and duration of analgesia lasting several hours, supporting use in moderate to severe postoperative pain.
What is Tegileridine Fumarate's receptor selectivity profile, and how does this translate to its safety profile compared to traditional opioids?
It is a selective mu-opioid receptor agonist with reduced potential for respiratory depression and dependence, though still requires careful monitoring.
What is the main adverse effect profile of Tegileridine Fumarate?
Common effects include nausea, vomiting, dizziness, and sedation; rare but serious risks include respiratory depression and hypotension.
Why is Tegileridine Fumarate indicated specifically for abdominal surgery pain?
It provides effective analgesia without significant impact on gastrointestinal motility, which is beneficial for postoperative recovery in abdominal surgery patients.
AiSuTe® | Tegileridine Fumarate Injection | Moderate to Severe Pain after Abdominal Surgery | DengYueRX
INN: Tegileridine Fumarate Injection
Indications: Relief of moderate to severe acute postoperative pain following abdominal surgery.
Dosage Form: Injection
Strength: 1ml: 1mg/vial; 5ml: 5mg/vial
