Description
Indication & Scope
Vemurafenib Film-coated Tablets (Zelboraf®) selectively inhibits mutant BRAF V600 kinase, blocks abnormal MAPK signaling pathway, suppresses proliferation and induces apoptosis of BRAF V600-mutated melanoma cells.
- Mechanism
Inhibit BRAF V600 mutant kinase, block MAPK oncogenic signaling - Drug class
Oral selective BRAF targeted film-coated tablets - Clinical use
BRAF V600 positive advanced melanoma and postoperative adjuvant treatment
| Generic Name | Vemurafenib Film-coated Tablets |
| Brand Name | Zelboraf® |
| Ingredient | Vemurafenib |
| Dosage Form | Film-coated Tablets |
| Package | 240mg*56 tablets/box |
| Conditions Treated | Unresectable or metastatic BRAF V600 mutation-positive melanoma; Adjuvant therapy for completely resected BRAF V600 mutation-positive melanoma |
| Taboos | Hypersensitivity to vemurafenib or excipients, pregnancy and lactation |
| Place of origin | Segrate (MI) , Italy |
| Priscription Type | Prescription drug (Rx) |
| Storage Conditions | Seal and store below 30°C, avoid light and moisture |
| Manufacturer | Delpharm Milano S.r.l. |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20170124 |
| Approval Date | January 17, 2022 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: 960mg (4 tablets of 240mg) twice daily orally, morning and evening, 12 hours apart.Take with or without food; swallow whole, do not crush or chew
Time: Take at the same time every 12 hours, consistently with or without food, swallow whole without crushing/chewing
Interaction: Strong CYP3A4 inhibitors significantly increase vemurafenib exposure; strong CYP3A4 inducers reduce efficacy, avoid concomitant use
Side effects: Arthralgia, rash, photosensitivity, fatigue, alopecia, diarrhea; severe risks: secondary cutaneous malignancies, severe skin toxicities, hepatic damage, retinal disorders, QT interval prolongation
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What specific gene mutation is required for Zelboraf administration?
BRAF V600 mutation.
Can vemurafenib tablets be chewed or crushed?
No, take whole tablets.
Two main indications of vemurafenib?
Advanced unresectable/metastatic melanoma and adjuvant therapy after complete resection.
What special malignant adverse reaction should be monitored?
New onset secondary cutaneous squamous cell carcinoma.
Zelboraf® | Vemurafenib Film-coated Tablets | Metastatic Melanoma | DengYueRX
INN: Vemurafenib
Indications: Metastatic Melanoma
Dosage Form: Film-coated Tablets
Strength: 240mg/Tablet
Original price was: $975.38.$829.07Current price is: $829.07.
