Description
Indication & Scope
Azathioprine converts to 6-mercaptopurine in vivo, blocking purine synthesis and inhibiting proliferation of T and B lymphocytes. It suppresses abnormal autoimmune response and reduces transplant rejection.
- Mechanism
Purine antagonist immunosuppressant - Drug class
Oral systemic immunosuppressant / Anti-rejection & autoimmune disease therapeutic tablets - Clinical use
Purine antagonist immunosuppressant; inhibits lymphocyte proliferation, used for transplant anti-rejection and autoimmune disease control.
| Generic Name | Azathioprine Tablets |
| Brand Name | Sine®; Imuran® |
| Ingredient | Azathioprine |
| Dosage Form | Film-coated Tablets |
| Package | 50mg*60 tablets/box; 50mg*100 tablets/box |
| Conditions Treated | Prophylaxis of acute rejection after allogeneic organ transplantation; treatment of multiple autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and lupus nephritis. |
| Taboos | Patients hypersensitive to azathioprine or any excipients are forbidden. Pregnancy and lactation are not recommended. |
| Place of origin | China; Germany; South Africa |
| Priscription Type | Prescription Drug |
| Storage Conditions | Sealed, store below 30°C, protected from light |
| Manufacturer | Shanghai Sine Pharmaceutical Laboratories Co., Ltd. |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | H31021422; HJ20170288 |
| Approval Date | January 10, 2025; July 04, 2025 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: Oral administration, swallowed whole with sufficient water after meals.
Time: 1.5–4mg/kg daily, once or divided into multiple doses.
Instructions for use: Regular blood routine and liver function monitoring are required. Avoid breaking or crushing tablets. Effective contraception is required for patients of childbearing age.
Interaction: Allopurinol significantly increases azathioprine toxicity; dosage must be greatly reduced when combined. Concurrent use with other myelosuppressive drugs raises hematologic risks.
Side effects: Leukopenia, liver function abnormality, nausea, vomiting.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indicatiaon, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What are the main clinical uses of azathioprine?
Prevent organ transplant rejection and treat various autoimmune diseases.
Which drug will drastically increase its toxicity?
Allopurinol.
Who cannot use the tablets?
Patients with allergy to it.
Can pregnant women take this medicine?
Not recommended due to teratogenic risk.
Sine® | Azathioprine Tablets | Autoimmune Diseases | DengYueRX
INN: Azathioprine
Indications: Autoimmune Diseases
Dosage Form: Film-coated Tablets
Strength: 50mg/Tablet
Price range: $9.41 through $43.37
