Description

Indication & Scope

Mepem®/ShuLuoKe® is a prescription carbapenem antibiotic indicated for the treatment of susceptible moderate to severe bacterial infections in adults and children aged 3 months and older. It is also indicated for empirical therapy in febrile neutropenia in adults.

Mechanism: Meropenem is a broad-spectrum carbapenem antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), resulting in rapid bactericidal activity against susceptible Gram-positive, Gram-negative, and anaerobic bacteria.
Drug class: Carbapenem β-lactam antibiotic.
Clinical use: Treatment of severe pneumonia, complicated urinary tract infections, intra-abdominal infections, gynecological infections, skin and soft tissue infections, bacterial meningitis, septicemia, and empirical treatment of febrile neutropenia.

Specification

Generic Name	Meropenem for Injection
Brand Name	Mepem®; ShuLuoKe®
Ingredient	Meropenem
Dosage Form	Powder for Injection
Package	0.5 g/vial 0.25 g/vial
Conditions Treated	Severe bacterial infections
Taboos	Hypersensitivity to meropenem, carbapenems, or other β-lactam antibiotics; concomitant use with valproic acid/divalproex sodium should generally be avoided
Place of origin	Japan; China
Prescription type	Prescription Drug (Rx)
Storage Conditions	Store below 25°C in a dry place. Protect from light. Reconstituted solution should be used within the recommended stability period.
Manufacturer	Sumitomo Pharma Co., Ltd. Oita Plant; CSPC Ouyi Pharmaceutical Co., Ltd.
Registration Authority	National Medical Products Administration (NMPA), China
Approval Number	HJ20140702; H20103094
Approval Date	December 26, 2023; May 22, 2024
Shelf Life	36 months; 24 months

How to use ?

Recommended Dose: Adults: 0.5–1 g IV every 8 hours; up to 2 g every 8 hours for bacterial meningitis. Adjust the dose in patients with renal impairment.

Time: Administer by intravenous injection (about 5 minutes) or intravenous infusion (15–30 minutes) every 8 hours.

Instructions for use: For intravenous use only. Reconstitute before administration and use promptly. Complete the prescribed treatment course even if symptoms improve.

Interaction: Avoid concomitant use with valproic acid/divalproex sodium. Probenecid may increase meropenem exposure. Monitor INR when used with warfarin.

Side effects: Common adverse reactions include diarrhea, nausea, vomiting, headache, rash, injection-site reactions, and elevated liver enzymes. Serious adverse reactions include hypersensitivity reactions, seizures, Clostridioides difficile-associated diarrhea, and severe skin reactions.

Important Notice

This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indication, and regional regulatory requirements.

Packaging & Shipping

Packaging

Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.

Shipping Methods

Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.

Export Support