Description
Indication & Scope
Sorafenib Tosylate Tablets (Nexavar®) is dual multi-target kinase inhibitor. It inhibits Raf serine/threonine kinase and VEGFR/PDGFR tyrosine kinases, suppresses tumor cell proliferation and angiogenesis to restrain tumor growth.
- Mechanism
Block Raf, VEGFR, PDGFR kinases, inhibit tumor proliferation and angiogenesis - Drug class
Oral multi-target anti-angiogenic film-coated tablets - Clinical use
Unresectable liver cancer, advanced kidney cancer, radioiodine-resistant differentiated thyroid cancer
| Generic Name | Sorafenib Tosylate Tablets |
| Brand Name | Nexavar® |
| Ingredient | Sorafenib Tosylate |
| Dosage Form | Film-coated Tablets |
| Package | 0.2g*60 tablets/box |
| Conditions Treated | Unresectable hepatocellular carcinoma (HCC); Advanced renal cell carcinoma (RCC); Differentiated thyroid carcinoma (DTC) refractory to radioactive iodine therapy |
| Taboos | Hypersensitivity to sorafenib or excipients, pregnancy and lactation |
| Place of origin | Leverkusen, Germany |
| Priscription Type | Prescription drug (Rx) |
| Storage Conditions | Seal and store below 25°C, avoid light and moisture |
| Manufacturer | Bayer AG |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20160201 |
| Approval Date | December 20, 2024 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: 0.4g (2 tablets) orally twice daily, taken without food at least 1 hour before or 2 hours after meals, Reduce to 0.4g once daily or suspend medication for severe toxic reactions
Time: Continuous administration until disease progression or intolerable adverse reactions
Interaction: Avoid strong CYP3A4 inducers/inhibitors; monitor coagulation function if combined with warfarin
Side effects: Hand-foot skin reaction, diarrhea, rash, fatigue, hypertension, alopecia; severe risks: hemorrhage, gastrointestinal perforation, cardiac ischemia, liver damage
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
Why cannot it be taken with meals?
High-fat food reduces sorafenib absorption.
What core kinases does sorafenib inhibit?
Raf, VEGFR and PDGFR.
Is sorafenib a chemotherapy drug?
Sorafenib is an oral multi-kinase targeted therapy, not chemo. It blocks cancer-promoting kinases to restrain tumor growth and angiogenesis.
Can sorafenib cause hair loss?
Nexavar® | Sorafenib Tosylate Tablets | HCC, RCC and DTC | DengYueRX
INN: Sorafenib Tosylate
Indications: HCC (Hepatocellular Carcinoma), RCC (Renal Cell Carcinoma) and DTC (Differentiated Thyroid Carcinoma)
Dosage Form: Film-coated Tablets
Strength: 0.2g/Tablet
Original price was: $1,350.76.$1,148.14Current price is: $1,148.14.
