Description
Indication & Scope
Sunitinib Malate Capsules (Sutent®) is multi-target tyrosine kinase inhibitor. It inhibits VEGFR, PDGFR, c-KIT, FLT3 and RET, suppresses tumor angiogenesis and tumor cell proliferation, induces apoptosis of tumor cells.
- Mechanism
Inhibit VEGFR/PDGFR/c-KIT multiple kinases, block angiogenesis and tumor growth - Drug class
Oral multi-target anti-angiogenic hard gelatin capsules - Clinical use
Imatinib-resistant GIST, advanced renal cell carcinoma, metastatic pancreatic neuroendocrine tumors
| Generic Name | Sunitinib Malate Capsules |
| Brand Name | Sutent® |
| Ingredient | Sunitinib Malate |
| Dosage Form | Hard Gelatin Capsules |
| Package | 12.5mg*28 capsules/bottle |
| Conditions Treated | Unresectable/metastatic gastrointestinal stromal tumor (GIST) after imatinib failure; Advanced renal cell carcinoma (RCC); Well-differentiated pancreatic neuroendocrine tumors (pNET) with unresectable metastatic lesions |
| Taboos | Hypersensitivity to sunitinib or excipients, pregnancy and lactation |
| Place of origin | Ascoli Piceno, Italy |
| Priscription Type | Prescription drug (Rx) |
| Storage Conditions | Store below 25°C, sealed and away from light |
| Manufacturer | Pfizer Italia S.r.l. |
| Registration Authority | National Medical Products Administration (NMPA) |
| Approval number | HJ20171137 |
| Approval Date | July 29, 2022 |
| Shelf Life | 36 months |
How to use ?
Recommended Dose: GIST & advanced RCC: 50mg once daily orally, take for 4 weeks, stop for 2 weeks (6-week full cycle), with or without food; Progressive unresectable metastatic pNET: 37.5mg once daily, continuous administration without scheduled rest period; Dose adjustment: Reduce dose by 12.5mg each step for grade 3/4 toxicities
Time: Swallow capsules whole; monitor blood pressure, thyroid function and routine blood tests regularly
Interaction: Avoid strong CYP3A4 inhibitors/inducers
Side effects: Fatigue, diarrhea, hand-foot skin reaction, hypertension, myelosuppression, yellow skin discoloration; severe risks: cardiac dysfunction, severe hypertension, hemorrhage, liver injury
Important Notice
This product shall only be used for post-exposure rabies prophylaxis by professional medical staff. It must be applied combined with rabies vaccine and injected via wound infiltration plus intramuscular routes as specified. Do not administer intravenously or alter the dosage at will. Hypersensitivity monitoring is required throughout the whole injection process.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What main kinases does sunitinib inhibit?
VEGFR, PDGFR and c-KIT.
Can sunitinib be taken on an empty stomach?
Yes, administration with or without food is acceptable.
Does sunitinib shrink tumors?
Sunitinib, a protein kinase-targeted inhibitor, blocks kinases fueling cancer cell growth to halt or shrink tumors.
What cardiovascular index needs close monitoring?
Blood pressure and cardiac function.
Sutent® | Sunitinib Malate Capsules | RCC, GIST and PNET | DengYueRX
INN: Sunitinib Malate
Indications: RCC (renal cell carcinoma), GIST (gastrointestinal stromal tumor) and PNET (pancreatic neuroendocrine tumors)
Dosage Form: Hard Gelatin Capsules
Strength: 12.5mg/Capsule
Original price was: $765.88.$651.00Current price is: $651.00.
