Description
Indication & Scope
AiRuiJing® Zeprumetostat Tablets provides monotherapy for adult patients with relapsed or refractory peripheral T-cell lymphoma after at least one prior systemic chemotherapy regimen.
- Mechanism: Zeprumetostat is a selective histone deacetylase (HDAC) inhibitor. It suppresses HDAC enzyme activity, increases histone acetylation levels in T-lymphoma tumor cells, regulates tumor suppressor gene expression, inhibits malignant T-cell proliferation and induces tumor cell apoptosis.
- Drug class: Epigenetic anti-tumor agent; oral histone deacetylase inhibitor.
- Clinical use: Salvage treatment for recurrent/refractory peripheral T-cell lymphoma for patients who failed frontline chemotherapy; achieves durable disease remission for relapsed hematological malignancies.
| Generic Name | Zeprumetostat Tablets |
| Brand Name | AiRuiJing |
| Ingredient | Zeprumetostat |
| Dosage Form | Tablets |
| Package | 50mg*98 tablets/box |
| Conditions Treated | Relapsed or refractory peripheral T-cell lymphoma in adult populations |
| Taboos | Known severe hypersensitivity to HDAC inhibitors or tablet excipients; patients with active severe hepatic failure |
| Place of origin | China |
| Prescription type | Prescription-only |
| Storage Conditions | Seal and store at controlled room temperature 15°C–25°C, shield from direct sunlight and excessive humidity |
| Manufacturer | HengRui Pharmaceutical, Ltd. |
| Registration Authority | National Medical Products Administration (NMPA), China |
| Approval number | H20250057 |
| Approval Date | Aug 26, 2025 |
| Shelf Life | 24 months |
How to use ?
Recommended Dose: 100 mg orally twice daily for standard adult treatment cycles. Dose reduction to 50 mg twice daily for persistent grade 3 toxicities.
Time: Administer every 12 hours with consistent timing, independent of meal intake.
Instructions for use: Swallow tablets whole with water; avoid grapefruit and grapefruit juice during treatment due to CYP3A4 interaction. Complete weekly blood cell count and liver function testing.
Interaction: CYP3A4 inhibitors increase systemic drug exposure and thrombocytopenia risk; warfarin and anticoagulants raise bleeding risk when co-administered.
Side effects:
1. Common adverse reactions: thrombocytopenia, neutropenia, fatigue, nausea, elevated liver enzymes, diarrhea.
2. Severe toxicities: severe myelosuppression, tumor lysis syndrome, severe cardiac arrhythmia.
Important Notice
This product should be administered only by qualified healthcare professionals in accordance with the approved prescribing information and local clinical guidelines. Dosage and administration may vary depending on patient condition, indicatiaon, and regional regulatory requirements.
Packaging & Shipping
Packaging
Original manufacturer’s packaging with secure export carton. Customized export packaging is available upon request.
Shipping Methods
Express Courier (EMS, DHL, FedEx, UPS), Air Freight, and Sea Freight. Cold-chain transportation is available for products requiring temperature-controlled logistics.
Export Support
Certificate of Analysis
GMP Certificate
Commercial Invoice
Packing List & CPP
Cold Chain Logistics
Customs Documentation
Scientific and regulatory sources
FAQ
What is the main clinical use of Zeprumetostat Tablets?
It is used for monotherapy of adult patients with relapsed or refractory peripheral T-cell lymphoma after at least one prior chemotherapy.
What is the standard administration dose and frequency of Zeprumetostat Tablets?
The standard dose is 100 mg orally twice a day at 12-hour intervals.
What drugs will interact with Zeprumetostat Tablets and increase medication risks?
CYP3A4 inhibitors and anticoagulants such as warfarin will increase the risk of adverse reactions.
What are the typical hematological adverse reactions of Zeprumetostat Tablets?
Typical hematological side effects include thrombocytopenia and neutropenia.
AiRuiJing® | Zeprumetostat Tablets | T-Cell Lymphoma | DengYueRX
INN: Zeprumetostat Tablets
Indications: Relapsed or refractory peripheral T-cell lymphoma
Dosage Form: Tablets
Strength: 50mg/tablet
